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Merck
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文件

46401

Supelco

环己酰亚胺，大包装

PESTANAL®, analytical standard

同義詞:

3- [2-（3,5-二甲基-2-氧代环己基）-2-羟乙基]戊二酰亚胺, 放线菌酮, 纳拉霉素A

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About This Item

經驗公式（希爾表示法）:
C15H23NO4
CAS號碼:
66-81-9
分子量：:
281.35
Beilstein:
88868
EC號碼:
200-636-0
MDL號碼:
MFCD00082346
分類程式碼代碼:
41116107
PubChem物質ID:
329757163
NACRES:
NA.24

等級

analytical standard

品質等級

100

描述

mixture of stereo isomers

產品線

PESTANAL®

化驗

≥95% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

溶解度

H2O: slightly soluble

抗生素活性譜

fungi

應用

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

格式

neat

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI 密鑰

YPHMISFOHDHNIV-FSZOTQKASA-N

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相關類別

一般說明

环己酰亚胺是一种具有显著抗真菌特性的抗生素。它由产链霉素的灰色链霉菌菌株产生，并通过抑制蛋白质合成发挥作用。它的主要生物学活性是真核生物中的翻译抑制，从而导致细胞生长停滞和细胞死亡。它被用作杀菌剂。
根据废除91/414指令的第1107/2009号法规（EC），环己酰亚胺未被批准在欧盟使用。

應用

环己酰亚胺可能有以下用途：
  • 评估环己酰亚胺作为 Optisol GS 补充剂的抗真菌疗效和安全性
  • 研究环己酰亚胺对切叶蚁工蚁的影响
  • 研究链霉素、环己酰亚胺、菌唑、克菌丹、呋喃丹、乐果和五氯硝基苯对土壤微生物的影响
  • 半干旱草地一氧化二氮生产的真菌控制研究
  • 链霉素和环己酰亚胺在土壤中的活性及其降解研究

生化／生理作用

作用机制：真核生物中的翻译抑制导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。

活性谱：具有抑制酵母和真菌如念珠菌、曲霉、酵母菌和青霉的活性

法律資訊

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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分析證明 (COA)

Lot/Batch Number
BCCM3154
BCCL9551
BCCL4263
BCCG8626
BCCG4773

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