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MAIPN4550

Millipore

Multiscreen® 96孔板，疏水性PVDF膜

pore size 0.45 μm, non-sterile

同義詞:

Hydrophobic 96-Well Plate, PVDF 96-Well Plate, PVDF Membrane Plate

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About This Item

分類程式碼代碼:
41104923
eCl@ss:
32039006
NACRES:
NB.22
暫時無法取得訂價和供貨情況

材料

PVDF membrane (hydrophobic)
acrylic
flat bottom wells

品質等級

400

描述

Non-sterile, clear 96-well filter plate with 0.45 um pore size Hydrophobic PVDF membrane for Avidin-biotin Linkages, DNA-binding Proteins, Protein Binding & PAMPA. Comes in a pack of 50.

無菌

non-sterile

產品線

MultiScreen®

特點

hydrophobic
lid

製造商／商標名

MultiScreen®

參數

50-250 μL sample volume (per well)

技術

parallel artificial membrane permeation assay (PAMPA): suitable

過濾面積

0.3 cm2

板尺寸

96 wells

孔最大容積

300 μL

有效容積

50-250 μL

基質

Immobilon®-P

孔徑

0.45 μm pore size

結合類型

high binding surface

運輸包裝

ambient

相關類別

應用

MultiScreen®-IP滤板，0.45 μm，透明，非无菌已用于：
  • 在平行人工膜渗透试验(PAMPA)中用作人工膜支撑和接收板，以测定肟的渗透性[1]
  • 酶联免疫斑点(ELISpot)检测[2]
  • 钥孔戚血蓝素(KLH)特异性ELISPOT，用于抗原(Ag)特异性细胞的鉴定[3]

法律資訊

Immobilon is a registered trademark of Merck KGaA, Darmstadt, Germany
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany

分析證明 (COA)

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Claudia Giesecke et al.
Journal of immunology (Baltimore, Md. : 1950), 200(12), 3981-3992 (2018-05-08)
There are currently limited insights into the progression of human primary humoral immunity despite numerous studies in experimental models. In this study, we analyzed a primary and related secondary parenteral keyhole limpet hemocyanin (KLH) immunization in five human adults. The
A C Belkina et al.
Journal of dental research, 99(7), 855-862 (2020-03-19)
Periodontitis (PD) is a common source of uncontrolled inflammation in obesity-associated type 2 diabetes (T2D). PD apparently fuels the inflammation of T2D and associates with poor glycemic control and increased T2D morbidity. New therapeutics are critically needed to counter the
Hee Chun Jeong et al.
Bioorganic & medicinal chemistry, 17(17), 6213-6217 (2009-08-12)
A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. Permeability measurements, using the Parallel Artificial Membrane Permeation Assays (PAMPA) method, were

文章

Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)

This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.

Membrane Integrity Test for Lipid-PAMPA Artificial Membranes

This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes

Permeability & Solubility Analysis Workflow

Combining solubility & PAMPA assays streamlines drug permeability testing.

條款

HDM-PAMPA 搭配 MultiScreen 滲透性濾板

預測口服藥物被動吸收的實驗在藥物發現過程中已變得越來越重要。正如 Faller 和 Kansy 之前所描述的，此類檢測提供了快速、低成本和自動化的方法來測量化合物的被動滲透性。

HDM-PAMPA with the MultiScreen Permeability Filter Plate

Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.

Guidelines for Bioassays on MultiScreen Filter Plates: Protein Binding and Cell Loading

Guidelines for various bioassays on the MultiScreen system, which makes it possible to carry out an assay from sample incubation to scintillation counting in a 96-well plate.

Questions

  1. Could you please explain the meaning of the terms "donor," "acceptor," "receiver," and "collection" in relation to MAIPN4550 and MAIPN4510 filter plates?

    1 answer

    1. The donor plate is also known as the filter plate, while the acceptor plate can be referred to as the acceptor, receiver, or collection plate. For detailed information on the PAMPA assay, you can refer to the provided link. Additionally, a datasheet is available that reviews some of the donor and acceptor plates. The donor plates include MAIPN4550 and MAIPNTR10. An alternative donor plate option is S2EM004M99, which is a 'MA' classic designed plate. It is important to note that any plate starting with 'MS---' in the catalog number cannot be used.

      As for the acceptor plates, several options are available, such as MSSACCEPT0R, MATRNPS50, and MSCPNUV40.

      Moreover, tech notes for the automation of PAMPA-Lipid on the Sciclone ALH 3000 workstation and the automation of PAMPA-HDM using a MultiScreen® Filter Plate on a Beckman Biomek® FX Workstation are also available. An article titled "Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)" provides further insights into the topic.

      Helpful?

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