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Merck
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重要文件

141101P

Avanti

极性脑提取液

Avanti Research™ - A Croda Brand

同義詞:

脑极性脂质提取物（猪）

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About This Item

CAS號碼:
86088-88-2
MDL號碼:
MFCD00066101
分類程式碼代碼:
12352211
NACRES:
NA.25
暫時無法取得訂價和供貨情況

形狀

powder

包裝

pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)

製造商／商標名

Avanti Research™ - A Croda Brand

脂質類型

lipid extracts

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

脑极性脂质提取物是通过丙酮沉淀后再用乙醚提取丙酮不溶物而提取自总脂质提取物的。
脑极性脂质提取物的主要脂质组分为磷脂酰乙醇胺。它还含有磷脂酰丝氨酸和磷脂胆酰碱。所含微量组分包括磷脂酸和磷脂酰肌醇。

應用

脑极性脂质提取物用于平行人工膜渗透模型 (PAMPA) 的膜制备，以评估血脑屏障渗透性[1][2]和研究药物渗透性。[3]

生化／生理作用

来自脑、肝、肾等哺乳动物组织的脂质提取物可用于建立膜模型，模拟天然生物膜。[4]脑脂质（尤其是极性组分）在对朊病毒种子的淀粉样蛋白形成的抑制中起重要作用。[5]

包裝

5 mL透明玻璃密封安瓿（141101P-100mg）
5 mL透明玻璃密封安瓿（141101P-500mg）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

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Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
Estefanía de Munck et al.
PloS one, 11(9), e0162723-e0162723 (2016-09-16)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
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