推薦產品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
AXO 49, monoclonal
物種活性
Apis, porcine, snail, pig, sea urchin, protista, sheep, mouse, lemur, Drosophila, Paramecium, trout
應無反應活性
Euglena, human (cilia)
技術
dot blot: suitable
immunofluorescence: suitable
western blot: suitable
同型
IgG1κ
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... TUBA1A(7846)
一般說明
已经在真核细胞中鉴定了微管蛋白的几种翻译后修饰。 糖基化是一种多修饰，其发生在纤毛草履虫的轴丝微管蛋白中鉴定的可变长度的甘氨酸链的侧向分支中。已经在许多单细胞和多细胞生物的微管蛋白和/或纤毛/鞭毛上检测到这种修饰。细胞质和轴丝室之间不同的聚糖基化微管蛋白亚型的差异分布表明，微管蛋白的聚糖基化水平在细胞水平上受到高度调节。AXO49抗体主要对运动性纤毛和鞭毛的轴丝微管蛋白具有反应性，这些纤毛和鞭毛被聚甘氨酰化。在某些情况下，还可以在其他非常稳定的微管网络上观察到反应性。该抗体可用于纤毛和鞭毛检测。
特異性
该抗体可识别含有至少3个甘氨酸残基的聚合物的侧向连接分支。该抗体与聚甘氨酰化微管蛋白以及其他聚甘氨酰化蛋白具有交叉反应性。
免疫原
草履虫纤毛（草履虫轴丝）的不溶性部分
應用
使用该小鼠单克隆抗体（抗泛聚甘氨酰化微管蛋白抗体，克隆AXO 49，经验证可用于蛋白质印迹和免疫荧光&斑点印迹）检测微管蛋白。
品質
通过蛋白质印迹法评估草履虫的总细胞骨架蛋白。：该抗体以1:50,000稀释度在10 µg草履虫总细胞骨架蛋白中检测到聚糖基化微管蛋白。
標靶描述
观测分子量〜55 kDa
外觀
形式：纯化
其他說明
浓度：关于批次特定浓度请参见检验报告。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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A useful model for determining the mechanisms by which actin and actin binding proteins control cellular architecture is the Drosophila melanogaster process of spermatogenesis. During the final step of spermatogenesis, 64 syncytial spermatids individualized as stable actin cones move synchronously
Sara Molina-Gil et al.
Nature communications, 14(1), 5730-5730 (2023-09-16)
The re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also been
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Biology open, 10(8) (2021-08-07)
Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone. The ciliary gate allows the selective import and export of molecules such as transmembrane receptors and transport proteins. These
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Frontiers in cell and developmental biology, 10, 837486-837486 (2022-04-19)
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the "tubulin code"-the permutations of tubulin
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Autophagy, 17(9), 2565-2575 (2020-12-01)
Yeast Atg8 and its homologs are involved in autophagosome biogenesis in all eukaryotes. These are the most widely used markers for autophagy thanks to the association of their lipidated forms with autophagic membranes. The Atg8 protein family expanded in animals
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