推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
pale yellow
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
Clc1cc(ccc1)Nc2ncnc3c2cc(c(c3)OC)OC
InChI
1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChI 密鑰
GFNNBHLJANVSQV-UHFFFAOYSA-N
一般說明
表皮生长因子受体激酶（IC50 = 3 nM）与HER2 neu（IC50 >100 µM）和血小板衍生生长因子受体激酶（IC50 >100 µM）相比，是一种细胞渗透性、可逆性、ATP竞争性、高效和选择性的抑制剂。消除血管紧张素II（目录号05-23-0101）诱导的MAP激酶（ERK）激活。还可抑制4-羟基壬烯醛对EGFR激酶和MAP激酶的激活。下调ARF1活性并分散高尔基体结构。也可购买10 mM（1 mg/317 µl）AG 1478的DMSO溶液（目录号658548）。
生化／生理作用
主要靶标
表皮生长因子受体激酶
表皮生长因子受体激酶
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：3 nM，针对表皮生长因子受体激酶
警告
毒性：标准处理（A）
準備報告
仅在使用前再用水相缓冲液进行稀释。
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
其他說明
Pan, H., et al. 2008.J. Biol. Chem.283, In press.
Liu, W., et al. 1999.J. Cell Sci.112, 2409.
Eguchi, S., et al. 1998.J. Biol. Chem. 273, 8890.
Levitzki, A., and Gazit, A. 1995.Science267, 1782.
Fry, D.W., et al. 1994.Science265, 1093.
Osherov, N., and Levitski, A. 1994.Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994.Biochem.Pharmacol.48, 659.
Liu, W., et al. 1999.J. Cell Sci.112, 2409.
Eguchi, S., et al. 1998.J. Biol. Chem. 273, 8890.
Levitzki, A., and Gazit, A. 1995.Science267, 1782.
Fry, D.W., et al. 1994.Science265, 1093.
Osherov, N., and Levitski, A. 1994.Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994.Biochem.Pharmacol.48, 659.
法律資訊
根据美国专利号5,457,105和欧洲专利号0,566,266的许可证销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Alessandro Brombin et al.
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Melanocytes, the pigment-producing cells, are replenished from multiple stem cell niches in adult tissue. Although pigmentation traits are known risk factors for melanoma, we know little about melanocyte stem cell (McSC) populations other than hair follicle McSCs and lack key
S P Soltoff
The Journal of biological chemistry, 273(36), 23110-23117 (1998-08-29)
The activation of growth factor receptors and receptors coupled to heterotrimeric guanine nucleotide-binding proteins (G-proteins) can increase mitogen-activated protein (MAP) kinase activity in many cells. Previously, we demonstrated that the activation of G-protein-coupled P2Y2 receptors by extracellular ATP and UTP
Tong San Tan et al.
Journal of cell science, 134(19) (2021-10-14)
In the skin fragility disorder epidermolysis bullosa simplex (EBS), mutations in keratin 14 (K14, also known as KRT14) or keratin 5 (K5, also known as KRT5) lead to keratinocyte rupture and skin blistering. Severe forms of EBS are associated with
Mariana S Dias et al.
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Adeno-associated virus vectors (rAAV) are currently the most common vehicle used in clinical trials of retinal gene therapy, usually delivered through subretinal injections to target cells of the outer retina. However, targeting the inner retina requires intravitreal injections, a simple
Akito Kakiuchi et al.
Oncology reports, 45(4) (2021-03-03)
In human head and neck squamous cell carcinoma (HNSCC), the invasion and metastatic properties of cancer cells are promoted by junctional adhesion molecule‑A (JAM‑A) and claudin‑1; these are epithelial tight junction molecules regulated by histone deacetylases (HDACs) and transcription factor
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