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Merck
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文件

A7410

Sigma-Aldrich

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

同義詞:

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

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About This Item

經驗公式（希爾表示法）:
C6H8ClN7O · HCl · xH2O
CAS號碼:
2016-88-8
分子量：:
266.09 (anhydrous basis)
MDL號碼:
MFCD03703482
分類程式碼代碼:
12352200
PubChem物質ID:
24277817
NACRES:
NA.77

product name

Amiloride hydrochloride hydrate, ≥98% (HPLC), powder

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

mp

285-288 °C (dec.)

溶解度

H2O: 50 mg/mL, clear, yellow-green

起源

Perrigo

儲存溫度

room temp

SMILES 字串

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

InChI 密鑰

WDZJJRLYFQNCQL-UHFFFAOYSA-N

基因資訊

human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124)
mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544)
rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

應用

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

生化／生理作用

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Protect from light.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

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Tengis S Pavlov et al.
Journal of the American Society of Nephrology : JASN, 24(7), 1053-1062 (2013-04-20)
Various stimuli, including hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na(+) absorption in the kidney. Members of the EGF family are important for maintaining transepithelial Na(+) transport, but whether EGF influences ENaC, perhaps mediating salt-sensitive hypertension
Tiphaine Dejouvencel et al.
Blood, 115(10), 2048-2056 (2009-12-10)
Fibrinolysis and pericellular proteolysis depend on molecular coassembly of plasminogen and its activator on cell, fibrin, or matrix surfaces. We report here the existence of a fibrinolytic cross-talk mechanism bypassing the requirement for their molecular coassembly on the same surface.
Takanori Tsujimura et al.
The Journal of physiology, 597(11), 2949-2963 (2019-04-30)
Afferents carried by the superior laryngeal nerve play a primary role in the initiation of laryngeal mechanically evoked swallows in anaesthetized rats. Amiloride and its analogues inhibit swallowing evoked by mechanical stimulation, but not swallowing evoked by chemical and electrical
Hiu-Fung Yuen et al.
PloS one, 8(1), e54211-e54211 (2013-02-02)
The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The expression levels of TAZ and YAP
Cristina Matthewman et al.
American journal of physiology. Cell physiology, 311(6), C920-C930 (2016-10-21)
Hyperactivated DEG/ENaC channels cause neuronal death mediated by intracellular Ca2+ overload. Mammalian ASIC1a channels and MEC-4(d) neurotoxic channels in Caenorhabditis elegans both conduct Na+ and Ca2+, raising the possibility that direct Ca2+ influx through these channels contributes to intracellular Ca2+
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