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527450

Sigma-Aldrich

Imidazolo-oxindole PKR inhibitor C16

≥90% (HPLC), solid, PKR inhibitor, Calbiochem®

同義詞:

PKR 抑制剂

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About This Item

經驗公式（希爾表示法）:
C13H8N4OS
CAS號碼:
608512-97-6
分子量：:
268.29
MDL號碼:
MFCD06735404
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

PKR 抑制剂, The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

品質等級

100

化驗

≥90% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

orange to orange-brown

溶解度

DMSO: 5 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

[s]1c2c(nc1)ccc3c2\C(=C\c4nc[nH]c4)\C(=O)N3

InChI

1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

InChI 密鑰

VFBGXTUGODTSPK-BAQGIRSFSA-N

一般說明

一种咪唑-羟吲哚化合物，作为PKR的一种有效的ATP结合位点定向抑制剂。显示可有效抑制RNA诱导的PKR自磷酸化（IC50 =210 nM）并挽救PKR依赖性翻译阻断（IC50=100 nM）。也可以使用非活性对照（目录号 527455。显示可增加持久突触增强的晚期阶段，并增强小鼠的长期记忆。也可以50 mM的DMSO溶液（货号527451）提供。

生化／生理作用

主要靶标
PKR
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：210 nM抑制RNA诱导的PKR自磷酸化，100 nM挽救PKR依赖性翻译阻断

包裝

用惰性气体包装

警告

毒性：致癌/致畸（D）

重構

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

其他說明

Zhu, P.J., et al. 2011.Cell147, 1384.
Jammi, N.V., et al. 2003.Biochem.Biophys.Res. Commun.308, 50.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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