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Merck
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文件

527451

Sigma-Aldrich

PKR Inhibitor

InSolution, ≥90%

同義詞:

InSolution PKR Inhibitor, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I, C16

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About This Item

經驗公式（希爾表示法）:
C13H8N4OS
CAS號碼:
608512-97-6
分子量：:
268.29
MDL號碼:
MFCD06735404
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥90% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

InChI 密鑰

VFBGXTUGODTSPK-BAQGIRSFSA-N

一般說明

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.

生化／生理作用

Cell permeable: yes
Primary Target
PKR
Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他說明

Zhu, P.J., et al. 2011. Cell147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點（°C）

87 °C - closed cup - (Dimethylsulfoxide)

分析證明 (COA)

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Narasimham V Jammi et al.
Biochemical and biophysical research communications, 308(1), 50-57 (2003-08-02)
The RNA-dependent protein kinase (PKR) is an interferon-induced serine/threonine protein kinase that phosphorylates the alpha subunit of the eukaryotic initiation factor 2 in response to viral infection. Classical genetic approaches for studying the role of PKR in cell signaling have
Ping Jun Zhu et al.
Cell, 147(6), 1384-1396 (2011-12-14)
The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while
Harikrishnan Radhakrishnan et al.
Bioengineering & translational medicine, 9(1), e10605-e10605 (2024-01-09)
Primary T cell has been transformed into a cell-based delivery platform that synthesizes complex biologics at the disease site with spatiotemporal resolution. This broadly applicable technology can circumvent toxicities due to systemic administration of biologics that necessitates the use of
Mor Angel et al.
Nucleic acids research, 52(9), 5356-5375 (2024-02-17)
Stress granules (SGs) are cytoplasmic assemblies formed under various stress conditions as a consequence of translation arrest. SGs contain RNA-binding proteins, ribosomal subunits and messenger RNAs (mRNAs). It is well known that mRNAs contribute to SG formation; however, the connection between SG

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