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Merck
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重要文件

428021

Sigma-Aldrich

Latrunculin A

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem

同義詞:

红海海绵素A，来源于Latrunculia magnifica

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About This Item

經驗公式（希爾表示法）:
C22H31NO5S
CAS號碼:
76343-93-6
分子量：:
421.55
MDL號碼:
MFCD27977552
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

红海海绵素A，来源于Latrunculia magnifica, Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

品質等級

100

描述

Merck USA index - 14, 8378

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 25 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C\C=C/[C@H](CC3)C)\C)C2)O

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

InChI 密鑰

DDVBPZROPPMBLW-IZGXTMSKSA-N

一般說明

一种可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。1 mM（50 µg/119µ l）的Latrunculin A，Latrunculia magnifica目录号 428026的DMSO溶液也可用。
来自红海海绵Latrunculia magnifica的可渗透细胞的海洋毒素，通过与单体G-肌动蛋白（Kd=200 nM）形成1：1的复合物来破坏培养细胞中的微丝组织。也是精子，卵子和胚胎中微丝介导过程的有效抑制剂。

生化／生理作用

与单体G-肌动蛋白形成1：1复合物中Kd=200 nM
主要靶标
G-肌动蛋白
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有

包裝

用惰性气体包装

警告

毒性：有害（C）

重構

复溶后等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

其他說明

Ayscough, K.R., et al. 1997.J. Cell Biol. 137, 399.
Spector, I., et al. 1989.Cell Motil.Cytoskeleton 13, 127.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Schatten, G., et al. 1986.Exp.Cell Res. 166, 191.
Spector, I., et al. 1983.Science 219, 493.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding membranes. The mechanism and control of lattice assembly, curvature, and vesicle formation at the plasma
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