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重要文件

428020

Sigma-Aldrich

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem®

同義詞:

红海海绵素B,Latrunculia magnifica

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About This Item

經驗公式(希爾表示法):
C20H29NO5S
CAS號碼:
分子量::
395.51
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

红海海绵素B,Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

品質等級

描述

Merck USA index - 14, 5378

化驗

≥95% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

顏色

off-white to yellow

溶解度

DMSO: 25 mg/mL
ethanol: 25 mg/mL
methanol: 50 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChI 密鑰

NSHPHXHGRHSMIK-JRIKCGFMSA-N

一般說明

一种结构独特的海洋毒素。在体外抑制肌动蛋白的聚合并破坏微丝组织以及微丝介导的过程。效力比细胞松弛素高 10 至 100 倍。

生化/生理作用

主靶
肌动蛋白聚合
产物不与ATP竞争。
可逆:否
细胞渗透性:否

警告

毒性:有害(C)

其他說明

Spector, I., et al. 1989.Cell Motil.Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988.Life Sci.43, 1825.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Spector, I., et al. 1983.Science219, 493.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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