推薦產品
product name
(-)-Blebbistatin, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
品質等級
化驗
≥98% (HPLC)
形狀
solid
效力
2 μM IC50
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
yellow
溶解度
methanol: 1.5 mg/mL
100% DMSO: 100 mg/mL
90% DMSO: 75 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI 密鑰
LZAXPYOBKSJSEX-GOSISDBHSA-N
一般說明
（±）-blebbistatin（目录编号203390）的活性对映体，其对ATP酶（IC50 = ~2 µM）和肌球蛋白II依赖性细胞过程具有抑制活性。还报道了强效抑制表达的平滑肌肌球蛋白IIA（SMA）和平滑肌肌球蛋白IIB（SMB）平滑肌肌球蛋白II重链亚型的肌动球蛋白ATP酶活性（IC50 ~3 µM）。
（±）-blebbistatin（目录编号203390）的活性对映体，其对ATP酶（IC50 ~2 µM）和肌球蛋白II依赖性细胞过程具有抑制活性。还报道了强效抑制表达的平滑肌肌球蛋白IIA（SMA）和平滑肌肌球蛋白IIB（SMB）平滑肌肌球蛋白II重链亚型的肌动球蛋白ATP酶活性（IC50 ~3 µM）。
生化／生理作用
产物不与ATP竞争。
可逆：否
细胞渗透性：否
包裝
用惰性气体包装
警告
毒性：有害 & 致癌/致畸性（E）
重構
复溶后，等分并冷冻保存（-20°C）。储备液在90%DMSO或甲醇（-20°C）中可稳定长达1个月。100%DMSO中的储备溶液不稳定；临用前复溶。
其他說明
Eddinger, T.J. et al. 2007.J. Pharmacol.Exp.Ther.320, 865.
Shu, S., et al. 2005.Proc.Natl.Acad.Sci. USA102, 1472.
Kovacs, M., et al. 2004.J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003.Science299, 1743.
Shu, S., et al. 2005.Proc.Natl.Acad.Sci. USA102, 1472.
Kovacs, M., et al. 2004.J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003.Science299, 1743.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Andrew D Doyle et al.
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T cell activation is sensitive to the mechanical properties of an activating substrate. However, there are also contrasting results on how substrate stiffness affects T cell activation, including differences between T cells of mouse and human origin. Towards reconciling these
Charlotte Canet-Jourdan et al.
Journal of cell science, 135(14) (2022-06-16)
The metastatic progression of cancer remains a major issue in patient treatment. However, the molecular and cellular mechanisms underlying this process remain unclear. Here, we use primary explants and organoids from patients harboring mucinous colorectal carcinoma (MUC CRC), a poor-prognosis
Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments.
Pag??s, et al.
Science Advances, 8, eabp8416-eabp8416 (2022)
Adam Germain et al.
Oncology, 102(6), 515-524 (2023-11-27)
Cancers in general, and specifically lung cancer, continue to have low patient survival rates when the patient is at an advanced stage when diagnosed. It appears that the local environment, especially fibroblasts and their signaling molecules, tends to induce metastasis
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