368055

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• 同義詞: Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO
• 經驗公式（希爾表示法）: C₂₁H₃₄N₄O₁₀
• CAS號碼: 1258003-96-1
• 分子量：: 502.52
• MDL號碼: MFCD01318858
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: DMSO: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N([C@@H]([C@@H](O)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)[C@H](CC)C)CCC(=O)O
• InChI 密鑰: AXTKTZHLZLOIIO-WBOIFEBMSA-N

描述

一般說明

A potent, reversible inhibitor of granzyme B and caspase-8 (K_i = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

Potent, reversible granzyme B and caspase-8 inhibitor.

生化／生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 1 nM against caspase-8

警告

Toxicity: Standard Handling (A)

序列

Ac-Ile-Glu-Thr-Asp-CHO

其他說明

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable