推薦產品
product name
颗粒酶B抑制剂I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
off-white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
生化／生理作用
主要靶标
颗粒酶B
颗粒酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：300 nM，针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告
毒性：标准处理（A）
序列
Z-Ala-Ala-Asp-CH₂Cl
重構
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他說明
Gong, B., et al. 1999.Cell Growth Different.10, 491.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
Yan Su et al.
Cell discovery, 8(1), 35-35 (2022-04-20)
Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
Ganta Vijay Chaitanya et al.
Brain pathology (Zurich, Switzerland), 21(1), 16-30 (2010-09-10)
Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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