推薦產品
品質等級
形狀
solid
製造商／商標名
Upstate®
技術
activity assay: suitable (kinase)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
應用
Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases.
The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
生化／生理作用
Protein Target: p38/SAPK2
Target Sub-Family: CMGC
Inhibitor Type: Kinase
品質
Routinely evaluated in a kinase assay as an inhibitor.
外觀
C20H14FN3O
儲存和穩定性
3 years at -20°C
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation
Orr, A. W., et al
The Journal of Biological Chemistry, 277, 20453-20460 (2002)
Katsushi Yamamoto et al.
The Journal of biological chemistry, 278(36), 34525-34532 (2003-06-25)
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) evokes the ER stress response. The resultant outcomes are cytoprotective but also proapoptotic. ER chaperones and misfolded proteins exit to the secretory pathway and are retrieved to the ER, during
R M Kramer et al.
The Journal of biological chemistry, 271(44), 27723-27729 (1996-11-01)
The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A2 in human platelets. We have previously shown that thrombin activates p38 kinase, a recently discovered new member of the
Z Li et al.
Biochemical and biophysical research communications, 228(2), 334-340 (1996-11-12)
We have identified a third member of the p38 group of MAP kinase termed p38 gamma. The cDNA for this MAP kinase encodes an 367 amino acid polypeptide that is slightly greater than 60% identical to p38 and p38 beta.
J C Lee et al.
Nature, 372(6508), 739-746 (1994-12-22)
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated
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