The optimal working concentration of the product is cell type and application dependent. Typically, a working concentration in the range of 0.5 to 2 uM is recommended.
推薦產品
品質等級
描述
RTECS - XZ3012000
化驗
≥98% (HPLC)
形狀
lyophilized
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
溶解度
methanol: 1 mg/mL
50% acetic acid: 25 mg/mL
DMSO: 25 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI 密鑰
XAUDJQYHKZQPEU-UHFFFAOYSA-N
一般說明
一种作为DNA甲基转移酶抑制剂的胞嘧啶类似物。在TRAIL抗性细胞系中恢复caspase-8和caspase-10 mRNA和蛋白表达以及TRAIL（肿瘤坏死因子相关凋亡诱导配体）敏感性。也增强HDAC（组蛋白去乙酰化酶）抑制剂诱导的凋亡。也可以提供100 mM的DMSO溶液（目录号189826）。
生化／生理作用
主要靶标
DNA甲基转移酶抑制剂
DNA甲基转移酶抑制剂
包裝
用惰性气体包装
警告
毒性：有害 & 致癌/致畸性（E）
準備報告
需要加热才能完全溶解
重構
复溶后，等分并冷冻（-20°C）。 储备液在-20°C条件下可稳定保存3个月。
其他說明
Eggert, A., et al. 2001.Cancer Res.61, 1314.
Takebayashi, S., et al. 2001.Biochem.Biophys.Res. Commun.288, 921.
Zhu, W.G., et al. 2001.Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000.Cancer Res.60, 4315.
Haaf, T. 1995.Pharmacol.Ther.65, 19.
Jones, P.A., and Taylor, S.M.1980.Cell20, 85.
Takebayashi, S., et al. 2001.Biochem.Biophys.Res. Commun.288, 921.
Zhu, W.G., et al. 2001.Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000.Cancer Res.60, 4315.
Haaf, T. 1995.Pharmacol.Ther.65, 19.
Jones, P.A., and Taylor, S.M.1980.Cell20, 85.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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