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LM4113

Avanti

25-hydroxycholesterol (D6)

Avanti Research™ - A Croda Brand

同義詞:

cholest-5-ene-3β,25-diol(d6)

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About This Item

經驗公式（希爾表示法）:
C27H40D6O2
CAS號碼:
88247-69-2
分子量：:
408.69
分類程式碼代碼:
12352100
NACRES:
NA.25
暫時無法取得訂價和供貨情況

形狀

methanol solution

包裝

pkg of 1 × 1 mL (LM4113-1EA)

製造商／商標名

Avanti Research™ - A Croda Brand

濃度

~10 μg/mL (Refer to C of A for lot specific concentration. )

應用

lipidomics
metabolomics

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

InChI

1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1/i2D3,3D3

InChI 密鑰

INBGSXNNRGWLJU-KHKDDIDZSA-N

一般說明

25-hydroxycholesterol is an oxygenated sterol[1] and a hydroxylated derivative of cholesterol.[2]

生化／生理作用

25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase.[1] It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.[2]

包裝

2 mL Amber Glass Sealed Ampule (LM4113-1EA)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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分析證明 (COA)

Lot/Batch Number

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Christopher M Adams et al.
The Journal of biological chemistry, 279(50), 52772-52780 (2004-09-29)
The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both involving the proteins that control sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors that activate genes encoding enzymes of lipid
Rosamaria Lappano et al.
PloS one, 6(1), e16631-e16631 (2011-02-10)
The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis. 25 HC is detectable in human
Cholsoon Jang et al.
Nature medicine, 22(4), 421-426 (2016-03-08)
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie this link remain unclear. Insulin resistance in skeletal muscle stems from the excess accumulation of lipid species, a process that
Ken Cheng et al.
Journal of agricultural and food chemistry, 66(33), 8876-8884 (2018-07-26)
Membrane lipids, including sphingolipids and glycerol-phospholipids, are essential in maintaining the skin's barrier function in mammals, but their composition in fish skin and their response to diets have not been evaluated. This study investigated the impacts of reducing dietary eicosapentaenoic

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