推薦產品
描述
cholest-5-ene-3β,25-diol-d6
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (700053P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
25-羟基胆固醇（25HC）在氧气和胆固醇 25-羟化酶存在下由胆固醇合成，并且在 toll 样受体激活过程中转化依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）。25HC 分解代谢为 7α-羟基化甾醇。[1]25-羟基胆固醇-d6 是 25-羟基胆固醇的氘代形式。
應用
生化／生理作用
包裝
5 mL 棕色玻璃螺旋盖样品瓶（700053P-1mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
閃點（°F）
No data available
閃點（°C）
No data available
Editorial: 25-Hydroxycholesterol: a new life in immunology.
Jeffrey G McDonald et al.
Journal of leukocyte biology, 88(6), 1071-1072 (2010-12-03)
Stian Solheim et al.
The Journal of steroid biochemistry and molecular biology, 192, 105309-105309 (2019-02-20)
Oxysterols can contribute to proliferation of breast cancer through activation of the Estrogen Receptors, and to metastasis through activation of the Liver X Receptors. Endogenous levels of both esterified and free sidechain-hydroxylated oxysterols were examined in breast cancer tumours from
Elizabeth S Gold et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10666-10671 (2014-07-06)
Cross-talk between sterol regulatory pathways and inflammatory pathways has been demonstrated to significantly impact the development of both atherosclerosis and infectious disease. The oxysterol 25-hydroxycholesterol (25HC) plays multiple roles in lipid biosynthesis and immunity. We recently used a systems biology
Ying Liu et al.
Journal of lipid research, 59(3), 439-451 (2018-01-05)
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes. However, the mechanisms regulating CH25H expression have not been fully elucidated. In this study, we determined that CH25H is
Pallavi Mukherjee et al.
Journal of lipid research, 58(8), 1636-1647 (2017-06-09)
Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all P < 0.0001). WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as
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