860815P

16:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860815P, powder

• 同義詞: N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine
• 經驗公式（希爾表示法）: C₃₄H₆₇NO₄
• CAS號碼: 34839-02-6
• 分子量：: 553.90
• MDL號碼: MFCD22416671
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 形狀: powder
• 包裝: pkg of 1 × 25 mg (860815P-25mg); pkg of 1 × 5 mg (860815P-5mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 860815P
• 脂質類型: sphingolipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO

描述

一般說明

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis.[1] 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.[2]

生化／生理作用

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling.[3] They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide.[2] hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans.[3] The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.[4]

包裝

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3