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917222

A1V2PF1-NHEt

Name: A1V2PF1-NHEt
Brand: ALDRICH

≥95%

同義詞:

(S)-1-((S)-2-((S)-2-Aminopropanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block

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About This Item

經驗公式（希爾表示法）:

C₂₇H₄₁N₅O₄

分子量：:

499.65

MDL號碼:

MFCD33021750

分類程式碼代碼:

41116105

NACRES:

NA.22

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Sigma-Aldrich

916714

A1V2PF2-NHEt

Sigma-Aldrich

920711

3-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid

Sigma-Aldrich

D5782

2′,3′-二脱氧胞苷

Sigma-Aldrich

917710

A1V1PF2-OEt

Sigma-Aldrich

917478

BocA1V1PF2

B1908

Nalgene^® centrifuge bottles, wide-mouth with sealing caps Style 3140

Sigma-Aldrich

919381

CCW16

Sigma-Aldrich

806439

2,6-Difluoroanilino(oxo)acetic acid

Sigma-Aldrich

917931

A1V2PF2-NHEt-C₆-NH₂

Sigma-Aldrich

917966

BocA1V2PF1-NHC₆-NH₂

ligand

A1V2PF1

品質等級

100

化驗

≥95%

形狀

powder

反應適用性

reagent type: ligand

官能基

amine

儲存溫度

2-8°C

SMILES 字串

N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O)C

InChI

1S/C27H41N5O4/c1-3-29-25(34)21(17-19-11-6-4-7-12-19)30-26(35)22-15-10-16-32(22)27(36)23(31-24(33)18(2)28)20-13-8-5-9-14-20/h4,6-7,11-12,18,20-23H,3,5,8-10,13-17,28H2,1-2H3,(H,29,34)(H,30,35)(H,31,33)/t18-,21-,22-,23-/m0/s1

InChI 密鑰

OMNNTFDLWROHJN-QGQQZZQASA-N

應用

A1V2PF1-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF1-NHEt is also available as BocA1V2PF1 (916978).

A1V2PF1-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks
916943 A1V2PF1-NHEt-C₆-NH₂
917206 A1V2PF1-NHEt-C₁₀-NH₂
917451 A1V2PF1-NHEt-PEG₁-NH₂
917702 A1V2PF1-NHEt-PEG₃-NH₂

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

其他說明

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.

Tasuku Ishida et al.

SLAS discovery : advancing life sciences R & D, 26(4), 484-502 (2020-11-05)

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new modality of chemical tools and potential therapeutics to understand and treat human disease. A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to

SNIPERs-Hijacking IAP activity to induce protein degradation.

Mikihiko Naito et al.

Drug discovery today. Technologies, 31, 35-42 (2019-06-16)

The induction of protein degradation by chimeric small molecules represented by proteolysis-targeting chimeras (PROTACs) is an emerging approach for novel drug development. We have developed a series of chimeric molecules termed specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein

Nobumichi Ohoka et al.

The Journal of biological chemistry, 292(11), 4556-4570 (2017-02-06)

Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach that may have utility in drug development relies

文章

Degrader Building Blocks with IAP In Silico-Derived Ligands

Targeted protein degradation reduces disease-relevant proteins in cells using small molecules, hijacking endogenous proteolysis systems.

Accelerating Protein Degrader Discovery with IAP

Plate of 80 ligands against E3 ligase IAP designed by ComInnex; allows creation of bifunctional targeted protein degraders or molecular glues.

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

針對蛋白質降解的降解器構件

Protein Degrader Building Blocks 是一系列交聯劑-E3 配體結合物，具有懸垂功能基團，可與目標配體共價連結。

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A1V2PF1-NHEt

≥95%

About This Item

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ligand

品質等級

化驗

形狀

反應適用性

官能基

儲存溫度

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InChI

InChI 密鑰

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