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Merck
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重要文件

901379

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 2, carboxyl, 1 NHBoc (core), generation 1

同義詞:

PFd-G1-BOCNH-COOH, bis-MPA dendron

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About This Item

經驗公式(希爾表示法):
C29H47NO17
分子量::
681.68
分類程式碼代碼:
12162002
暫時無法取得訂價和供貨情況

形狀

solid

分子量

generation 1

號表面基團

2

顏色

white to off-white

儲存溫度

−20°C

一般說明

  • Polymer architecture: Dendron
  • Generation: 1
  • Core functional group: Boc-protected amine
  • End Group Functionality: Carboxylic acid
  • No. Surface Groups: 2
  • Calculated Mol. Wt.: 681.69 g/mol
  • Boc: tert-Butyloxycarbonyl
  • bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

應用

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

文章

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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