推薦產品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
1C9.1, monoclonal
物種活性
human, rat
技術
immunohistochemistry: suitable
western blot: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... NLGN1(22871)
一般說明
Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.
免疫原
Epitope: Extracellular domain
GST-tagged recombinant protein corresponding to the extracellular domain of Human Neuroligin-1.
應用
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Neuroligin-1 in human cerebral cortex, rat cerebellum and rat cerebral cortex tissue.
Research Category
Neuroscience
Neuroscience
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Growth Cones & Axon Guidance
Synapse & Synaptic Biology
Growth Cones & Axon Guidance
This Anti-Neuroligin-1, clone 1C9.1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Neuroligin-1.
品質
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Neuroligin-1 in 10 µg of rat brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Neuroligin-1 in 10 µg of rat brain tissue lysate.
標靶描述
~94 kDa observed
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Julien Dufort-Gervais et al.
Scientific reports, 10(1), 6956-6956 (2020-04-26)
Synapse loss occurs early and correlates with cognitive decline in Alzheimer's disease (AD). Synaptotoxicity is driven, at least in part, by amyloid-beta oligomers (Aβo), but the exact synaptic components targeted by Aβo remain to be identified. We here tested the
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