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774405

Sigma-Aldrich

(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐

99% (titration)

同義詞:

(S)-2-氨基丁烷-1,4-二硫醇 盐酸盐, (2S)-2-氨基-1,4-二巯基丁烷 盐酸盐, DTBA, 二硫代丁胺

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About This Item

經驗公式(希爾表示法):
C4H11NS2 · HCl
CAS號碼:
分子量::
173.73
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

99% (titration)

形狀

solid

反應適用性

reagent type: reductant

mp

210-225 °C

儲存溫度

2-8°C

SMILES 字串

Cl.N[C@H](CS)CCS

InChI

1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1

InChI 密鑰

HWWPXJZINVJNBM-WCCKRBBISA-N

應用

二硫代丁胺或DTBA是一种新型生物还原剂,其性能优于其他常用试剂。DTBA被证明比DTT还原小分子二硫化物快3-5倍,并且与DTT相比,还原(激活)半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。另外,由于伯胺基的存在,使得从混合物中去除DTBA的过程变得更加简单,并且可以使用阳离子交换树脂来实现。
S)-2-氨基丁烷-1,4-二硫醇盐酸盐(DTBA),也称为二硫代丁胺,是一种生物还原剂,具有比其他常用试剂更高的性能。 DTBA被证明比DTT还原小分子二硫化物快3-5倍,并且与DTT相比,还原(激活)半胱氨酸依赖性蛋白酶木瓜蛋白酶的速度快14倍。[1][2] 另外,由于伯胺基的存在,使用后从混合物中去除DTBA的过程得到简化,并且可以使用阳离子交换树脂来实现。[1]

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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A potent, versatile disulfide-reducing agent from aspartic acid.
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Macroporous cell-laden hydrogels have recently gained recognition for a wide range of biomedical and bioengineering applications. There are various approaches to create porosity in hydrogels, including lyophilization or foam formation. However, many do not allow a precise control over pore
Javier Troyano et al.
Inorganic chemistry, 58(5), 3290-3301 (2019-02-13)
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3I3(TBA)2] n (4)
Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent.
Adamczyk J, et al.
Inorganic Chemistry, 54(2), 596-606 (2014)
Aiping Wen et al.
Materials science & engineering. C, Materials for biological applications, 111, 110759-110759 (2020-04-14)
Ovarian cancer is considered to be the most fatal reproductive cancers. Melphalan is used to treat ovarian cancer as an intraperitoneal chemotherapy agent. However, elucidating its pharmacokinetic behavior and preparing it for administration are challenging since it undergoes spontaneous hydrolysis.

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Raines lab innovations include traceless Staudinger ligation and DTBA reagent, advancing chemical biology research with Sigma-Aldrich.

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