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重要文件

729108

Sigma-Aldrich

聚乙二醇甲醚巯基

average MN 800, chemical modification reagent thiol reactive, methoxy, thiol

同義詞:

PEG 硫醇, mPEG 硫醇, 甲氧基 PEG 硫醇, 甲氧基聚乙二醇硫醇

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About This Item

線性公式:
CH3O(CH2CH2O)nCH2CH2SH
分類程式碼代碼:
12162002
NACRES:
NA.23
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產品名稱

聚乙二醇甲醚巯基, average Mn 800

形狀

solid

品質等級

分子量

average Mn 800

反應適用性

reagent type: chemical modification reagent
reactivity: thiol reactive

雜質

≤10% disulfide

轉變溫度

Tm 32-37 °C

Mw/Mn

≤1.1

Ω-end

thiol

α-end

methoxy

聚合物結構

shape: linear
functionality: monofunctional

儲存溫度

2-8°C

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應用

聚乙二醇单甲醚硫醇可用于 功能化修饰 Fe3O4@Au 核壳纳米颗粒。硫醇化的PEG提高水溶性 并显著降低纳米毒性。

它可作为前体合成用于基因治疗的PEG偶联 聚β氨基酯)复合物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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分析證明 (COA)

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存取文件庫

Cristina Gentilini, Mariangela Boccalon, and Lucia Pasquato
The Journal of Organic Chemistry, 3308-3308 (2008)
Nisha C. Kalarickal, Stephen Rimmer, Prodip Sarker, and Jean-Christophe Leroux
Macromolecules, 40, 1874-1874 (2007)

文章

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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