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Merck
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文件

390585

Sigma-Aldrich

次异羟肟酸

95%

同義詞:

软木肟酸, SBHA, 辛二酰基双异羟肟酸

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About This Item

線性公式:
[-(CH2)3CONHOH]2
CAS號碼:
分子量::
204.22
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

95%

mp

153-155 °C (lit.)

SMILES 字串

ONC(=O)CCCCCCC(=O)NO

InChI

1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)

InChI 密鑰

IDQPVOFTURLJPT-UHFFFAOYSA-N

生化/生理作用

软木肟酸(SBHA)是组蛋白脱乙酰基酶(HDAC)抑制剂。SBHA 抑制 HDAC1 和 HDAC3 的活性,IC50 值分别为 250 和 300 nM。SBHA 抑制增殖,并诱导几种癌细胞系的凋亡。研究表明,SBHA 可激活甲状腺髓样癌(MTC)细胞中的 Notch 信号传导。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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