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365645

Sigma-Aldrich

穿心莲内酯

98%

同義詞:

穿心莲内酯, 脱水穿心莲内酯

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About This Item

經驗公式(希爾表示法):
C20H30O5
CAS號碼:
分子量::
350.45
Beilstein:
42762
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

98%

形狀

powder

光學活性

[α]20/D −126°, c = 1.5 in acetic acid

mp

229-232 °C (lit.)

官能基

ester
hydroxyl

SMILES 字串

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

InChI

1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChI 密鑰

BOJKULTULYSRAS-OTESTREVSA-N

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一般說明

穿心莲内酯是一种具有生物活性的二萜内酯,是传统药物穿心莲的主要成分。已知其具有不同的生物活性,如抗炎[1]、抗疟疾、抗癌 [2] 和保肝活性。[3]对登革病毒也表现出强效的抗病毒作用。[4]

應用


  • 基于穿心莲内酯的 Keap1-Nrf2 通路药物候选物通过严格的化学信息学筛选:本研究确定了潜在的穿心莲内酯衍生物作为针对 Keap1-Nrf2 通路的创新药物候选物,这对于抗氧化防御机制至关重要。这种方法突出了化合物在开发治疗氧化应激相关疾病方面的多功能性,使其成为学术界和生物技术领域化学家和材料科学家的重要研究领域。(Jain 和 Sudandira Doss,2023 年)

  • 基于 TMT 的定量蛋白质组学揭示了穿心莲内酯对 LPS 诱导的肝损伤的靶点:这项对穿心莲内酯在肝损伤模型中诱导的蛋白质组学变化的调查,为其治疗机制提供了见解,突出了其作为炎症和肝病治疗的潜力,这与制药和生化领域的研发相关。(Ge 等人,2023 年)

  • 通过功能蛋白质组学研究共价作用天然产物的靶点和抗癌机制:本研究评估了穿心莲内酯在抗癌特性方面的作用,对其在分子水平上的相互作用进行了详细分析,这对于从事新型癌症治疗的材料科学家和化学家至关重要。(Zhao 等人,2023 年)

生化/生理作用

具有抗炎特性的双萜内酯。它可阻断外源刺激下的 T 细胞增殖和补体诱导的巨噬细胞趋化迁移。可阻断几种癌细胞系的体外增殖。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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In vitro and in vivo anti-inflammatory effects of andrographolide.
Abu-Ghefreh Ala'AA, et al.
International Immunopharmacology, 9(3), 313-318 (2009)
Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride.
Handa SS and Sharma A.
The Indian Journal of Medical Research, 92, 276-283 (1990)
Activity of andrographolide against dengue virus.
Panraksa P, et al.
Antiviral Research, 139, 69-78 (2017)
Eugenie Mussard et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-21)
Andrographis paniculata (Burm.f.) has long been used in ayurvedic medicine through its anti-inflammatory properties. However, its protective effect of skin aging has not been studied in vitro. This study aimed to investigate the anti-aging effects of methanolic extract (ME), andrographolide
Jonathan Chee Woei Lim et al.
Clinical and experimental pharmacology & physiology, 39(3), 300-310 (2011-10-25)
1. Andrographis paniculata (Burm. f) Nees, commonly known as 'king of bitters', is a herbaceous plant belonging to the Family Acanthaceae. It has been widely used for centuries in Asian countries like China, India, Thailand and Malaysia for the treatment of

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is the andrographolide can be detected by spectrophotometry UV-VIS ???

    1 answer
    1. Due to the presence of pi bonds in the molecular structure, Andrographolide has chromophores. As a result, this compound may be detected by UV-Vis spectrophotometry.
      Please see the link below to review a publication that may be helpful:
      https://www.pharmahealthsciences.net/pdfs/volume7-issue12019/8.vol7-issue1-2019-MS-15711.pdf

      Helpful?

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