Four phosphonamidates were synthesized as potential beta-lactamase inhibitors. Three were methanephosphonamidates [CH3PO2-NHR/Ar, where R/Ar = 4-methoxybenzyl (3a), phenyl (3b), and m-nitrophenyl (3c)], while the fourth, PhCH2OCONHCH2PO2-NHPh (2a), also contained a beta-lactamase active site-directed amido side chain. The pH-rate profiles for
Journal of chromatography. A, 1501, 99-106 (2017-04-25)
A target analysis method for the sensitive and discriminative determination of the nerve agent hydrolysis products alkyl methylphosphonic acids as their tert-butyldimethylsilyl (TBDMS) derivatives was developed using a combination of selectable one- and two-dimensional (
The Raman spectra of twenty-two chemical warfare agents (CWAs) were measured: eleven nerve agents and their precursor, five blister agents, three lachrymators, one choking agent, and one vomit agent, in liquid or solid state in colorless transparent vials were analyzed