P8953

Platelet-Derived Growth Factor from porcine platelets

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

• 别名: PDGF
• MDL编号: MFCD00166903
• UNSPSC代码: 12352202
• NACRES: NA.77

属性

• 产品名称: Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture
• 生物来源: Porcine
• 质量水平: 200
• 方案: ≥97% (SDS-PAGE and N-terminal analysis)
• 表单: lyophilized powder
• 效能: 39.00 ng/mL EC₅₀
• 质量: endotoxin tested
• 分子量: glycoprotein 38 kDa
• 包装: pkg of 5 μg
• 储存条件: avoid repeated freeze/thaw cycles
• 技术: cell culture | mammalian: suitable
• 杂质: ≤1 EU/μg
• 颜色: white
• UniProt登记号: P20034
• 储存温度: −20°C
• 基因信息: pig ... PDGFB(100626465)

说明

应用

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

生化/生理作用

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

外形

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

分析说明

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)