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Merck

P5585

Sigma-Aldrich

棕榈酸

BioXtra, ≥99%

别名:

C16:0, NSC 5030, 十六酸, 棕榈酸

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10 G
$145.00
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$210.00
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$581.00

$145.00


预计发货时间2025年4月01日详情


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10 G
$145.00
25 G
$210.00
100 G
$581.00

About This Item

线性分子式:
CH3(CH2)14COOH
CAS号:
分子量:
256.42
Beilstein:
607489
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.25

$145.00


预计发货时间2025年4月01日详情


获取大包装报价

生物来源

plant (vegetable)

等级

BioPerformance Certified

蒸汽压

10 mmHg ( 210 °C)

产品线

BioXtra

方案

≥99%

表单

powder

技术

cell culture | mammalian: suitable

杂质

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

灼烧残渣

≤0.1%

沸点

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

溶解性

chloroform: 0.5 M, clear, colorless

密度

0.852 g/mL at 25 °C (lit.)

痕量阴离子

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

官能团

carboxylic acid

脂质类型

saturated FAs

运输

ambient

储存温度

room temp

SMILES字符串

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

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应用

棕榈酸已被用于:
  • 作为胎盘绒毛组织培养物的培养基补充剂[1]
  • 作为激素小球的组分,用于小鼠卵巢植入[2]
  • 用于诱导人单核细胞THP-1的免疫相关GTP酶M(IRGM)的表达[3]

生化/生理作用

棕榈酸是一种直链16碳脂肪酸。 富含棕榈酸以及月桂酸和肉豆蔻酸的饮食,与血清中低密度脂蛋白胆固醇水平升高有关。 棕榈酸是脂肪生成过程产生的第一种脂肪酸。 它是乙酰辅酶A羧化酶(ACC)的负调节因子,与脂肪酸诱导的胰岛素抵抗有关。
棕榈酸(PA)是膜磷脂(PL)和脂肪三酰基甘油(TAG)的成分。[4]棕榈酸水平升高促进动脉粥样硬化、2型糖尿病、神经退行性疾病、肥胖和癌症的病理生理发展。[4][5]PA通过调节p38丝裂原活化蛋白激酶(MAPK)途径促进内皮细胞的凋亡,并有利于TNF-α的表达和活性氧的积累。[6]PA促进肝细胞中的白细胞介素8(IL-8)合成,导致肝炎。[7]PA通过与toll样受体4(TLR4)的相互作用,诱导心肌细胞的炎性损伤。[8]

储存分类代码

11 - Combustible Solids

WGK

nwg

闪点(°F)

235.4 °F

闪点(°C)

113 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Palmitic acid induced vascular endothelial cell apoptosis contributes to the high severity of coronary artery disease in the Uygur population
Jiang H, et al.
Biomedical Research, 28(2), 17339-17361 (2017)
Biological and nutritional properties of palm oil and palmitic acid: effects on health
Mancini A, et al.
Molecules (Basel), 20(9), 17339-17361 (2015)
Lipidomic Analysis of alpha Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Fanning S, et al.
Molecular Cell (2018)
Cangju Qinggan Jiangzhi Decoction Reduces the Development of NonAlcoholic Steatohepatitis and Activation of Kupffer Cells
Cheng Y, et al.
Cellular Physiology and Biochemistry, 48(3), 971-982 (2018)
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi-Barve S, et al.
Hepatology, 46(3), 823-830 (2007)

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脂肪组织中的胰岛素耐受性减少了循环游离脂肪酸的摄入,并增加了脂肪酶对储存甘油三酯的水解。了解与胰岛素耐受性相关的激素、细胞因子和脂肪因子。

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Questions

1–6 of 6 Questions  
  1. I want to know the storage temperature after reconstituting the product in the solvent? Also clarify regarding the type of solvent to be used?

    1 answer
    1. Unfortunately, the stability of this product in solution is not determined.

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  4. I am curious about the storage temperature of this product.

    1 answer
    1. As listed in the PROPERTIES section of the product page, this product may be stored at room temperature.

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  5. Can you tell me the storage temperature for this product?

    1 answer
    1. As stated in the PROPERTIES section of the product page, this product is stored at room temperature.

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  6. Is this product soluble only in chloroform? Did you know something about its solubility in ethanol or DMSO?

    1 answer
    1. Stock solutions of palmitic acid can be prepared in 200 proof ethanol or DMSO at 20 mg/mL. Stock solutions should be purged with inert gas, such as argon or nitrogen, prior to storage.

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