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F4765

盐酸氟奋乃静二盐酸盐

Name: 盐酸氟奋乃静 二盐酸盐
Brand: SIGMA

别名:

4- [3- [2-（三氟甲基）-10H-吩噻嗪-10-基]丙基] -1-哌嗪乙醇二盐酸盐

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About This Item

经验公式（希尔记法）:

C₂₂H₂₆F₃N₃OS · 2HCl

CAS号:

146-56-5

分子量:

510.44

EC 号:

205-674-1

MDL编号:

MFCD00055212

UNSPSC代码:

12352200

PubChem化学物质编号:

57654184

NACRES:

NA.77

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SMILES字符串

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChI key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

基因信息

human ... DRD1(1812) , DRD2(1813) , HRH1(3269)

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一般描述

Fluphenazine may be useful for the treatment of schizophrenia.[1]

应用

Fluphenazine dihydrochloride has been used:

to study its effects as a drug on glioblastoma (GBM) cells[2]
in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments[3]
to study its exposure effects on learning and memory in adult rats[4]

生化/生理作用

D₁/D₂多巴胺受体拮抗剂；吩噻嗪类抗精神病药；H₁组胺受体拮抗剂。

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H301,H360

预防措施声明

P201 - P301 + P310 + P330

危险分类

Acute Tox. 3 Oral - Repr. 1A

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM

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Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

Cheng HW, et al.

Cell Death & Disease, 6(5), e1753-e1753 (2015)

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