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D5294

Sigma-Aldrich

Dilazep dihydrochloride

powder

别名:

ASTA C 4898, Cormelian, N,N′-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride

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About This Item

经验公式（希尔记法）:
C31H44N2O10 · 2HCl
CAS号:
20153-98-4
分子量:
677.61
EC 号:
243-548-8
MDL编号:
MFCD00133267
UNSPSC代码:
12352200
PubChem化学物质编号:
24278372
NACRES:
NA.77
价格与库存信息目前不能提供

表单

powder

质量水平

200

颜色

white

溶解性

H2O: 10 mg/mL

储存温度

2-8°C

SMILES字符串

Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2

InChI

1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H

InChI key

VILIWRRWAWKXRW-UHFFFAOYSA-N

基因信息

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

一般描述

Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.[1]

应用

Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay.[2] It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.[3]

生化/生理作用

Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor.[1] It is an antianginal drug[2] and an effective coronary vasodilator.[4] Dilazep elicits anti-albuminuric effects and is an anti-platelet agent.[4] It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.[5]

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000350686
0000350687
0000262357
0000350687
0000350686

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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)
Playa H, et al.
Bioorganic & medicinal chemistry letters, 24(24), 5801-5804 (2014)
S M Delaney et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 568-572 (1998-05-15)
Selective inhibitors of adenosine production, degradation and transport were used to potentiate in vivo levels of adenosine and to determine the source of both basal and N-methyl-D-aspartate (NMDA)-induced increases in levels of endogenous adenosine in vivo. Male Sprague-Dawley rats receiving
H Deguchi et al.
Blood, 90(6), 2345-2356 (1997-10-06)
Dilazep, an antiplatelet agent, is generally used as an antithrombotic drug in clinical practice. Dilazep is also known to exert cytoprotective and antioxidant effects on endothelial cells. However, its effect on the endothelial or monocyte procoagulant activity is unknown. In
Daniel Krys et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13837-13851 (2019-10-12)
Elevated proliferation rates in cancer can be visualized with positron emission tomography (PET) using 3'-deoxy-3'-l-[18F]fluorothymidine ([18F]FLT). This study investigates whether [18F]FLT transport proteins are regulated through hypoxia. Expression and function of human equilibrative nucleoside transporter (hENT)-1, hENT2, and thymidine kinase
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
Iskar M, et al.
Molecular Systems Biology, 9(1), 662-662 (2013)
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