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Merck

G8503

Sigma-Aldrich

18α-甘草次酸

≥95%

别名:

18α-甘草次酸, 18-异甘草次酸, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid

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250 MG
$212.00
1 G
$686.00

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250 MG
$212.00
1 G
$686.00

About This Item

经验公式(希尔记法):
C30H46O4
CAS号:
分子量:
470.68
EC 号:
MDL编号:
UNSPSC代码:
12352115
PubChem化学物质编号:
NACRES:
NA.22

$212.00


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质量水平

方案

≥95%

SMILES字符串

[H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI key

MPDGHEJMBKOTSU-PMTKVOBESA-N

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一般描述

18α-甘草次酸 (18α-GA) 是一种在甘草中发现的具有生物活性的三萜类化合物。[1]其显示对 11-HSD1(11-羟基类固醇脱氢酶 1)的选择性抑制。[2]其对肝星状细胞 (HSC) 也有抗增殖和凋亡作用。[3]

应用

18α-甘草次酸可用于合成:[4]
  • 3-酮-18α-甘草次酸
  • 18α-甘草次酸甲酯
  • 3-酮基-18α-甘草次酸甲酯

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Selective inhibition of 11?-hydroxysteroid dehydrogenase 1 by 18a-glycyrrhetinic acid but not 18?-glycyrrhetinic acid.
Classen-Houben D, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 113(3), 248-252 (2009)
Sebastian M Goerke et al.
Tissue engineering. Part A, 18(23-24), 2395-2405 (2012-06-27)
Neovascularization represents an important issue in tissue-engineering applications, since survival of implanted cells strongly relies on sufficient oxygen and nutrient supply. We have recently observed that human bone marrow-derived mesenchymal stem cells (MSCs) support neovessel formation originating from coimplanted endothelial
Manuela Buonanno et al.
PloS one, 6(6), e21540-e21540 (2011-07-09)
An increased risk of carcinogenesis caused by exposure to space radiation during prolonged space travel is a limiting factor for human space exploration. Typically, astronauts are exposed to low fluences of ionizing particles that target only a few cells in
Mohammad Shahidullah et al.
American journal of physiology. Cell physiology, 302(12), C1751-C1761 (2012-04-12)
In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens epithelium and show that TRPV4 activation is an important step in the response of
Manuel Viotti et al.
PLoS biology, 10(3), e1001276-e1001276 (2012-03-14)
Establishment of left-right (LR) asymmetry occurs after gastrulation commences and utilizes a conserved cascade of events. In the mouse, LR symmetry is broken at a midline structure, the node, and involves signal relay to the lateral plate, where it results

Questions

1–3 of 3 Questions  
  1. What is the stability of Product G8503, 18α-Glycyrrhetinic acid, once in solution?

    1 answer
    1. Unfortunately, we don't have any solution stability data available for this product.

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  2. What is the solubility of Product G8503, 18α-Glycyrrhetinic acid?

    1 answer
    1. It is soluble in chloroform:ethanol (2:3) at a concentration of 20 mg/mL.  It is expected to be soluble in dimethyl sulfoxide (DMSO) as well.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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