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Merck

54802

Sigma-Aldrich

1-羟基苯并三唑 水合物

≥97.0% dry basis (T), for peptide synthesis

别名:

HOBt 一水合物

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10 G
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预计发货时间2025年1月27日详情


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10 G
$59.50

About This Item

经验公式(希尔记法):
C6H5N3O · xH2O
分子量:
135.12 (anhydrous basis)
Beilstein:
4515
EC號碼:
MDL號碼:
分類程式碼代碼:
12352000
PubChem物質ID:
NACRES:
NA.22

$59.50


预计发货时间2025年1月27日详情


获取大包装报价

产品名称

1-羟基苯并三唑 水合物, ≥97.0% dry basis (T)

品質等級

化驗

≥97.0% dry basis (T)

形狀

solid

成份

water, ~12%

反應適用性

reaction type: Addition Reactions

mp

155-158 °C (lit.)

溶解度

DMF: 0.1 g/mL, clear

應用

peptide synthesis

SMILES 字串

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

InChI 密鑰

PJUPKRYGDFTMTM-UHFFFAOYSA-N

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一般說明

1-羟基苯并三唑是一种偶联剂,用于活化酯/酸与保护氨基酸氨基之间发生缩合反应时合成酰胺。[1]此外,还用作肽合成过程中的外消旋作用抑制剂。[2]

應用

1-羟基苯并三唑水合物可用作缩合剂以:
  • 通过γ-谷氨基酸二聚体制备聚-γ-谷氨酸甲酯。[2]
  • 通过氨肟与三氟乙酸酐或苯甲酸衍生物的成环缩合反应制备恶二唑。[3]

其他說明

广泛应用于降低碳二亚胺肽偶联外消旋化的添加剂;[4] 肽段的无消旋缩合[5][6]

象形圖

FlameExclamation mark

訊號詞

Danger

危險聲明

危險分類

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

儲存類別代碼

4.1A - Other explosive hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

314.6 °F

閃點(°C)

157 °C


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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其他客户在看

Slide 1 of 1

1 of 1

T. Miyazawa et al.
Tetrahedron Letters, 25, 771-771 (1984)
Chemical synthesis of poly-?-glutamic acid by polycondensation of ?-glutamic acid dimer: Synthesis and reaction of poly-?-glutamic acid methyl ester
Sanda F, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 39(5), 732-741 (2001)
Synthesis of 3, 5-disubstituted 1, 2, 4-oxadiazoles and their behavior of liquid crystallines
Guo J, et al.
Tetrahedron Letters, 55(9), 1557-1560 (2014)
Oxyma-B, an excellent racemization suppressor for peptide synthesis
Jad YE, et al.
Organic & Biomolecular Chemistry, 12(42), 8379-8385 (2014)
S. Ishizuka et al.
Pept. Sci., 37, 39-39 (2001)

Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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