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Merck
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主要文件

8.51008

Sigma-Aldrich

TBTU

≥98.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate

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About This Item

经验公式(希尔记法):
C11H16BF4N5O
分子量:
321.08
MDL编号:
UNSPSC代码:
12352107
EC索引号:
423-040-4
NACRES:
NA.22
价格与库存信息目前不能提供

产品名称

TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®

质量水平

产品线

Novabiochem®

方案

≥98.0% (HPLC)

表单

powder

反应适用性

reaction type: Coupling Reactions

制造商/商品名称

Novabiochem®

mp

195-199 °C (decomposes)

应用

peptide synthesis

储存温度

15-25°C

SMILES字符串

[B+3].[F-].[F-].[F-].[F-].[N+](=C(N(C)C)O[n]1nnc2c1cccc2)(C)C

InChI

1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4

InChI key

SHGLJDNRZIDILW-UHFFFAOYSA-J

一般描述

See entry for HBTU (851006). TBTU has been employed to generate 1,2,4-oxadiazoles from carboxylic acids [1].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.

应用


  • Synthesis of phospho-urodilatin by combination of global phosphorylation with the segment coupling approach.: This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996).

  • Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.: The study investigates the impact of tertiary amines on carbodiimide-mediated peptide synthesis, highlighting the role of TBTU in enhancing peptide coupling efficiency (Beyermann et al., 1991).

联系

Replaces: 01-62-0015

分析说明

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

FlameExclamation mark

警示用语:

Danger

危险声明

危险分类

Flam. Sol. 1 - Skin Sens. 1A

储存分类代码

4.1A - Other explosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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