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Merck

47672

Sigma-Aldrich

Fmoc-Asn(Trt)-OH

≥97.0%, for peptide synthesis

别名:

Nα-(9-芴甲氧羰基)-Nγ-三苯甲基-L-天冬酰胺, Nα-Fmoc-Nγ-三苯甲基-L-天冬酰胺

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5 G
$90.30
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$129.00
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$378.00
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$1,980.00

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5 G
$90.30
25 G
$129.00
100 G
$378.00
1 KG
$1,980.00

About This Item

经验公式(希尔记法):
C38H32N2O5
分子量:
596.67
Beilstein:
4343823
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

$90.30


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产品名称

Fmoc-Asn(Trt)-OH, ≥97.0%

方案

≥97.0%

表单

powder

旋光性

[α]20/D −15.0±1°, c = 1% in methanol

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

mp

201-204 °C (lit.)

应用

peptide synthesis

官能团

Fmoc

储存温度

2-8°C

SMILES字符串

OC(=O)[C@H](CC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C38H32N2O5/c41-35(40-38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28)24-34(36(42)43)39-37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33/h1-23,33-34H,24-25H2,(H,39,44)(H,40,41)(H,42,43)/t34-/m0/s1

InChI key

KJYAFJQCGPUXJY-UMSFTDKQSA-N

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一般描述

Fmoc-Asn(Trt)-OH在大多数有机溶剂中具有良好的溶解性;与引入Asn [1, 2]的其他衍生物相比,采用这一成分可明显提高制得的多肽纯度。可通过标准程序进行偶联。三苯甲基通常可利用95%的TFA在1-3小时内去除,且Trp残基未烷基化。当Asn(Trt)为N端残基时,可能需要延长反应时间,确保完全脱保护[3]。

应用

Fmoc-Asn(Trt)-OH用于通过SPOT法在纤维素膜上合成多肽[1]

象形图

Environment

危险声明

危险分类

Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xiaoyi Mao et al.
STAR protocols, 2(2), 100503-100503 (2021-05-18)
Identification of peptides mediating protein-protein interaction (PPI) is crucial for understanding the function of interlinked proteins in cellular processes and amino acid-associated diseases. Traditional PPI assays are laborious, involving the generation of many truncated proteins. SPOT peptide assay allows high-throughput
Paul W R Harris et al.
Biopolymers, 104(2), 116-127 (2015-02-07)
The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail

相关内容

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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