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Merck

47695

Sigma-Aldrich

芴甲氧羰基-S-三苯甲基-L-半胱氨酸

≥95.0% (sum of enantiomers, HPLC)

别名:

N-(9-芴甲氧羰基)-S-三苯甲基-L-半胱氨酸, Nα-Fmoc-S-三苯甲基-L-半胱氨酸

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5 G
$99.80
100 G
$286.00
1 KG
$1,860.00

$99.80


预计发货时间2025年4月21日详情


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5 G
$99.80
100 G
$286.00
1 KG
$1,860.00

About This Item

经验公式(希尔记法):
C37H31NO4S
分子量:
585.71
Beilstein:
4221286
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

$99.80


预计发货时间2025年4月21日详情


获取大包装报价

方案

≥95.0% (sum of enantiomers, HPLC)

旋光性

[α]20/D +16.0±2°, c = 1% in THF

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

mp

170-173 °C (lit.)

应用

peptide synthesis

官能团

Fmoc

储存温度

2-8°C

SMILES字符串

OC(=O)[C@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46

InChI

1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/t34-/m0/s1

InChI key

KLBPUVPNPAJWHZ-UMSFTDKQSA-N

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一般描述

Fmoc-Cys(Trt)-OH是Fmoc固相肽合成中常用的氨基酸。 [1]

应用

Fmoc-Cys(Trt)-OH是一种N末端保护的半胱氨酸衍生物,可用于肽合成。一些例子包括:
  • 合成单官能和双官能化铂(IV)络合物以靶向血管生成肿瘤脉管系统。[2]
  • 通过固相合成将肽酰肼作为硫酯替代物进行天然化学连接来合成蛋白质。[3]
  • 通过将还原糖与肽的半胱氨酸残基缀合来合成糖结合物。[4]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Conjugated platinum (IV)? peptide complexes for targeting angiogenic tumor vasculature.
Mukhopadhyay S, et al.
Bioconjugate Chemistry, 19(1), 39-49 (2007)
Panchada Ch V Govindu et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 18(1), 198-207 (2018-11-14)
Avobenzone is the most widely used UVA filter in sunscreen lotion and it is prone to degradation in the presence of sunlight/UV radiation. To overcome the photo-instability of avobenzone, various photostabilizers have been used as additives, including antioxidants such as
Chemical synthesis of proteins using peptide hydrazides as thioester surrogates.
Zheng J S, et al.
Nature Protocols, 8(12), 2483-2483 (2013)
Parallel synthesis of structurally diverse aminobenzimidazole tethered sultams and benzothiazepinones
Sureshbabu D et al.
Tetrahedron Letters, 53, 6897-6900 (2012)
A double-click approach to the protecting group free synthesis of glycoconjugates.
Alexander S R, et al.
Organic & Biomolecular Chemistry, 16(8), 1258-1262 (2018)

相关内容

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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