- A microfluidic high-resolution NMR flow probe.
A microfluidic high-resolution NMR flow probe.
Journal of the American Chemical Society (2009-03-27)
Jacob Bart, Ard J Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J Nieuwland, Hans J W G Janssen, Jan P J M van Bentum, Kirsten A M Ampt, Floris P J T Rutjes, Sybren S Wijmenga, Han J G E Gardeniers, Arno P M Kentgens
PMID19320484
ABSTRAKT
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.