U6750

Uridine 5′-triphosphate trisodium salt hydrate

≥93.0% (HPLC), Thyroid hormone

• Synonim(y): UTP Na₃
• Wzór empiryczny (zapis Hilla): C₉H₁₂N₂Na₃O₁₅P₃ · xH₂O
• Numer CAS: 19817-92-6
• Masa cząsteczkowa: 550.09 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 24900658
• UNSPSC Code: 12352200
• EC Number: 243-347-5
• MDL number: MFCD00044310
• Beilstein/REAXYS Number: 3585234
• Assay: ≥93.0% (HPLC)
• Quality level: 200

Właściwości

• Nazwa produktu: Uridine 5′-triphosphate trisodium salt hydrate, Type IV, ≥93.0% (HPLC)
• InChI key: MMJGIWFJVDOPJF-LLWADOMFSA-K
• InChI: 1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
• SMILES string: [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
• type: Type IV
• assay: ≥93.0% (HPLC)
• solubility: H₂O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless
• storage temp.: −20°C
• Quality Level: 200

Opis

Application

UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells[1]. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis[2].

Uridine 5′-triphosphate has been used in a study to show that fluoxetine (FLX), mediates its anti-depressive effect by increasing the gliotransmission of adenosine 5′-triphosphate (ATP).

Biochem/physiol Actions

P2Y receptor agonist.

Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

25 mg of Uridine 5′-triphosphate trisodium salt (UTP Na₃) hydrate is soluble in 0.5 ml of water and yields a clear, colorless solution.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)