SRP5304

PDGFR-α (T674I), active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): CD140A, MGC74795, PDGFR2, Rhe-PDGFRA
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in baculovirus infected Sf9 cells
• linia produktu: PRECISIO^®
• Próba: ≥70% (SDS-PAGE)
• Postać: buffered aqueous glycerol solution
• aktywność właściwa: 16-24 nmol/min·mg
• masa cząsteczkowa: ~95 kDa
• numer dostępu NCBI: NM_006206
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... PDGFRA(5156)

Opis

Opis ogólny

PDGFR alpha (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFR alpha has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFR alpha in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFR alpha are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase. PDGFRa(T674I) is one of the mutant forms of PDGFRa.

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informacje prawne

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable