SML1898

Iguratimod

≥98% (HPLC)

• Synonim(y): 3-Formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one, IGU, N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide, N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide, T-614
• Wzór empiryczny (zapis Hilla): C₁₇H₁₄N₂O₆S
• Numer CAS: 123663-49-0
• Masa cząsteczkowa: 374.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00882374
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Właściwości

• InChI: 1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20)
• SMILES string: O=S(NC1=CC(OC=C(NC([H])=O)C2=O)=C2C=C1OC3=CC=CC=C3)(C)=O
• InChI key: ANMATWQYLIFGOK-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• Quality Level: 100

Opis

Biochem/physiol Actions

Iguratimod (T-614) is an orally active anti-inflammatory compound that inhibits NF-kappaB (NF-KB) p65 subunit (RelA) phosphorylation and nuclear translocation (30 μg/mL against 10 ng/mL TNF-α; human synovial cells) without affecting IKBα degradation.

Iguratimod (T-614) is an orally active anti-inflammatory compound that inhibits NF-kappaB p65 subunit (RelA) phosphorylation and nuclear translocation.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3