SML1800

JK-2

≥90% (NMR)

• Synonim(y): Lithium 2-(phenylphosphonothioylamino)-3-phenylpropanoate
• Wzór empiryczny (zapis Hilla): C₁₅H₁₄NO₃PS · 2Li
• Masa cząsteczkowa: 333.20
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329826073
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥90% (NMR)
• Postać: powder
• warunki przechowywania: desiccated; protect from light
• kolor: white to beige
• rozpuszczalność: H₂O: 20 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: S=P(C1=CC=CC=C1)([O-])NC(C([O-])=O)CC2=CC=CC=C2.[Li+].[Li+]

Opis

Działania biochem./fizjol.

JK-2 is a phosphorothioate-based hydrogen sulfide (H2S) donor that shows greatly accelerated H2S release upon protonation-induced intramolecular cyclization at acidic pH ([H2S]/time/pH = 94 μM/4.5 min/pH 5.0, 84 μM/4.5 min/pH 6.0, 36 μM/90 min/pH 7.4, 21 μM/90 min/pH 8.0 with JK-2; [JK-2] = 100 μM at time 0) and is superior to GYY4137 in H2S generation both in buffer (<5 μM H2S/90 min/pH 5.0-8.0 with GYY4137) and in cells without cytotoxicity up to 400 μM in H9c2 and HeLa cultures. JK-2 protects H9c2 rat myoblasts from anoxia/reoxygenation (A/R; 1 hr 2% O2, then 6 hr reoxygenation with 400 μM H2O2) treatment (100% vs. 60% viability with or without 25 μM JK-2) and is efficacious in reducing infarct size per area-at-risk (INF/AAR) upon myocardial ischemia-reperfusion (MI/R) injury induction in mice in vivo (55% and 56% INF/AAR redcution with 50 μg/kg and 100 μg/kg, respectively, via intracardiac injection).

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3