SMI-4a jest selektywnym, kompetycyjnym względem ATP inhibitorem kinazy Pim-1 z IC50 wynoszącym 21 nM dla Pim-1 w porównaniu do IC50 wynoszącego 100 nM dla Pim-2 i z niewielką lub zerową aktywnością wobec panelu 50 innych testowanych kinaz. Stwierdzono, że SMI-4a hamuje wzrost komórek raka prostaty i indukuje zatrzymanie cyklu komórkowego w fazie G1 w prekursorowych liniach komórkowych białaczki limfoblastycznej / chłoniaka z komórek T.
SMI-4a jest selektywnym, kompetycyjnym względem ATP inhibitorem kinazy Pim-1.
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