SMB00375

Nadifloxacin

≥98% (HPLC)

• Synonim(y): Nadifloxacin, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Acuatim, Jinofloxacin, OPC-7251, 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
• Wzór empiryczny (zapis Hilla): C₁₉H₂₁FN₂O₄
• Numer CAS: 124858-35-1
• Masa cząsteczkowa: 360.38
• Kod UNSPSC: 51102829
• NACRES: NA.85

Właściwości

• pochodzenie biologiczne: synthetic (Organic)
• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: white to yellow
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Tryb działania: DNA synthesis | interferes; enzyme | interferes
• temp. przechowywania: −20°C
• InChI: 1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
• Klucz InChI: JYJTVFIEFKZWCJ-UHFFFAOYSA-N

Opis

Opis ogólny

Chemical structure: fluoroquinolone

Nadifloxacin is antimicrobial in nature, and is a fluorinated quinolone. It is highly potent against Gram-negative and Gram-positive bacteria, especially Propionibacteruim acnes.[1]

Działania biochem./fizjol.

Nadifloxacin is used as a topical antibacterial, which is bactericidal due to its capability of preventing the negative supercoiling of bacterial DNA. DNA supercoiling, replication, transcription are catalyzed by DNA gyrase. In Japan, it is used to treat skin infection and acne.[2] Studies show, that nadifloxacin is capable of successfully treating green nail syndrome (GNS) caused by Pseudomonas aeruginosa.[3]

Przechowywanie i stabilność

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510) Non Combustible liquids.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Heat sensitive. Storage class (TRGS 510): Non Combustible Solids

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable