SAB4502380
Anti-PKC ζ antibody produced in rabbit
affinity isolated antibody
Synonim(y):
KPCZ, PKC-ζ, PKC2, PRKCZ, Protein kinase C ζ type
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 67 kDa
reaktywność gatunkowa
human, rat, mouse
stężenie
~1 mg/mL
metody
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... PRKCZ(5590)
Opis ogólny
Protein kinase C (PKC) ϲ is an isoenzyme, which belongs to the atypical class of protein kinase C family. PKCϲ is encoded by the gene mapped to human chromosome 1p36.33-p36.2. PKC ϲ is expressed in human eosinophils. This protein is characterized with a PB1 (Phox and Bem1) domain in the N-terminal, a pseudosubstrate (PS) sequence, a C1 domain (or phorbol esters/diacylglycerol binding domain) of a single Cys-rich zinc-finger motif, and a kinase domain in the C-terminal.
Immunogen
The antiserum was produced against synthesized peptide derived from human PKC zeta.
Immunogen Range: 526-575
Immunogen Range: 526-575
Zastosowanie
Anti-PKC ϲ, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.
Działania biochem./fizjol.
Isoenzymes of protein kinase C (PKC) family play a vital role in downstream signaling and cell functions. PKC ϲ regulates adhesion and effector functions of human eosinophils stimulated with platelet-activating factor (PAF) or complement (C) 5a. PKC ϲ and PKC δ might act as a therapeutic target for decreasing eosinophilic inflammation in clinical conditions such as asthma. PKC ϲ is calcium–independent, and is activated by phospholipids including phosphatidic acid (PA), phosphatidylinositol triphosphates and ceramides. Experimental studies state that, PKC ϲ is involved in the mitogen-activated protein kinase (MAPK) cascade, transcriptional factor NF-κB (NF-κB) activation, ribosomal S6-protein kinase signaling, and cell polarity. PKC-ϲ mediates hypoxia-induced Na,K-ATPase endocytosis in the alveolar epithelial cells (AEC).4 PKC-ϲ functions as a potential biomarker for human prostate cancer.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Andrew C Zelhof et al.
PLoS genetics, 16(6), e1008890-e1008890 (2020-06-25)
The Drosophila apical photoreceptor membrane is defined by the presence of two distinct morphological regions, the microvilli-based rhabdomere and the stalk membrane. The subdivision of the apical membrane contributes to the geometrical positioning and the stereotypical morphology of the rhabdomeres
Masahiko Kato et al.
Immunology, 116(2), 193-202 (2005-09-16)
Protein kinase (PK) C comprises a family of isoenzymes that play key roles in downstream signalling and cell functions. We studied PKC zeta participation in the effector functions of human eosinophils stimulated with platelet-activating factor (PAF) or complement (C) 5a.
Kutibh Chihabi et al.
Behavioral neuroscience, 130(6), 563-571 (2016-03-08)
Protein kinase M zeta (PKM-ζ), a constitutively active N-terminal truncated form of PKC-ζ, has long been implicated in a cellular correlate of learning, long-term potentiation (LTP). Inhibition of PKM-ζ with zeta-inhibitory peptide (ZIP) has been shown in many brain structures
Takaaki Hirai et al.
Journal of biochemistry, 133(1), 1-7 (2003-05-23)
The zeta isotype of protein kinase C (PKCzeta) is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. Increasing evidence from studies using in vitro and in vivo systems points to
Anna G McGrath et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(12), 2390-2398 (2018-08-17)
The constitutively active, atypical protein kinase C, protein kinase M-ζ (PKMζ), is exclusively expressed in the brain and its expression increases following exposure to drugs of abuse. However, the limitations of currently available tools have made it difficult to examine
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