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Merck

SAB4200678

Sigma-Aldrich

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

Synonim(y):

Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I

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About This Item

Kod UNSPSC:
51111800
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

COL-1, monoclonal

Formularz

buffered aqueous solution

reaktywność gatunkowa

pig, rat, human, deer, bovine

stężenie

~1 mg/mL

metody

ELISA: suitable
dot blot: suitable
immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum
immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

izotyp

IgG1

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... COL1A1(1277)

Opis ogólny

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogen

bovine skin collagen type I

Zastosowanie

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Działania biochem./fizjol.

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Odwiedź Bibliotekę dokumentów

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Gao Q, et al.
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Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma.
Simon M-P, et al.
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Uwe Schwartz et al.
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