SAB2702004

Anti-PPP1CB antibody produced in rabbit

• Synonim(y): PP-1B, PP1B, PP1beta, PPP1CD
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• białko sprzężone: unconjugated
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: liquid
• masa cząsteczkowa: 37 kDa
• reaktywność gatunkowa: human, mouse
• stężenie: 0.5 mg/mL
• metody: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 500-3000
• numer dostępu UniProt: P62140
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... PPP1CB(5500)

Opis

Opis ogólny

Protein phosphatase 1 catalytic subunit β (PPP1CB) gene is mapped to human chromosome 2p23.2. It is expressed in spines, dendrites, axon terminals, axons and glia in the prefrontal cortex. PPP1CB is expressed at higher levels in dendrites. It has a calcineurin-like phosphoesterase domain, a metallophosphatase domain and a serine/threonine protein phosphatase domain.

Immunogen

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 274 of PPP1CB

Zastosowanie

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Działania biochem./fizjol.

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
In the brain, protein phosphatase 1 catalytic subunit β (PPP1CB) regulates synaptic plasticity. Mutation in the gene causes intellectual disability (ID), congenital heart disease.

Cechy i korzyści

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Postać fizyczna

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H317,H412
• Zwroty wskazujące środki ostrożności: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Klasyfikacja zagrożeń: Aquatic Chronic 3 - Skin Sens. 1
• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable