S2671

Suramin sodium salt

≥98% (TLC)

• Synonim(y): Suramine sodium salt
• Wzór empiryczny (zapis Hilla): C₅₁H₃₄N₆Na₆O₂₃S₆
• Numer CAS: 129-46-4
• Masa cząsteczkowa: 1429.17
• Beilstein: 3694087
• Numer WE: 204-949-3
• Numer MDL: MFCD00210217
• Kod UNSPSC: 12352201
• Identyfikator substancji w PubChem: 24277738
• NACRES: NA.25

Właściwości

• Poziom jakości: 200
• Próba: ≥98% (TLC)
• Formularz: powder
• zanieczyszczenia: <15% water (Karl Fischer)
• kolor: white to light brown
• rozpuszczalność: H₂O: >10 mg/mL
• ciąg SMILES: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
• InChI: 1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6
• Klucz InChI: VAPNKLKDKUDFHK-UHFFFAOYSA-H
• informacje o genach: human ... EGF(1950) , FGF1(2246) , P2RX1(5023) , P2RY1(5028) , PDGFA(5154) , PLD1(5337)

Opis

Opis ogólny

Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins.[1] It is associated with urticaria, paresthesias, vomiting and neurologic toxicity.[2] Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.[3]

Zastosowanie

Suramin sodium salt has been used:

• as a potent blocker of rat P2Y₂ purinergic receptor[4]
• to study its effects on short circuit current (I_sc) across strial marginal cells[5]
• to show its effects on initial burst of glial activity[6]
• to assess its neuroprotective potential in rats[7]
• as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP)[8]

Działania biochem./fizjol.

Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.

Inne uwagi

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)