Unfortunately, we do not have any Protoporphyrin IX that is classified as non-animal origin.
P8293
Protoporphyrin IX
From Porcine, ≥95%, guanylyl cyclase activator, powder
Synonim(y):
3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, Kammerer’s porphyrin, Ooporphyrin
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1 G
1250,00 zł
1250,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C34H34N4O4
Numer CAS:
Masa cząsteczkowa:
562.66
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
209-033-7
MDL number:
Beilstein/REAXYS Number:
380795
Form:
powder
Assay:
≥95%
Solubility:
DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
Biological source:
Porcine
Przejdź do
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Pozwól nam pomócNazwa produktu
Protoporphyrin IX, ≥95%
InChI
1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-
InChI key
KSFOVUSSGSKXFI-UJJXFSCMSA-N
SMILES string
Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
biological source
Porcine
assay
≥95%
form
powder
solubility
DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
fluorescence
λex 402 nm; λem 625 nm (bound to HRP), λex 409 nm; λem 633 nm
storage temp.
2-8°C
Quality Level
Powiązane kategorie
1 of 4
Ta pozycja | |||
|---|---|---|---|
| solubility DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown | solubility - | solubility - | solubility - |
| assay ≥95% | assay ≥90% (HPLC) | assay 90% | assay ≥92% (HPLC) |
| biological source Porcine | biological source - | biological source - | biological source - |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. room temp |
| form powder | form powder | form solid | form powder |
General description
Protoporphyrin IX imparts red color to heme and is the major porphyrin in blood. It is synthesized from protoporphyrinogen IX in the presence of protoporphyrinogen IX oxidase.
Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.
Application
Activates soluble guanylyl cyclase.
Protoporphyrin IX has been used:
- as a standard in protoporphyrin assays[1]
- in fluorescence spectra analysis
- to treat cells in cell culture to study heme-mediated ferroportin 1 transcription
Biochem/physiol Actions
Protoporphyrin IX levels are elevated in tumor cells due to metabolism anomalies compared to normal cells.
Protoporphyrin IX penetrates human erythrocytes and aids the release of oxygen from them. It forms complexes with myoglobin and hemoglobin. It is a photosensitizer used in the photodynamic therapy of cancer.
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Numer produktu
Opis
Cennik
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Ki Mo Kim et al.
Environmental toxicology and pharmacology, 48, 85-93 (2016-10-23)
Coniferaldehyde (CA) exerts anti-inflammatory properties by inducing heme oxygenase-1 (HO-1). To define the regulation mechanism by which CA induces a cytoprotective function and HO-1 expression, the up-stream regulations involved in the activation of nuclear transcription factor-erythroid 2-related factor (Nrf)-2/HO-1 pathway
Aggregation Behavior of Protoporphyrin IX in Aqueous Solutions: Clear Evidence of
Vesicle Formation
Vesicle Formation
Luigi Monsu Scolaro
The Journal of Physical Chemistry B, 106, 2453-2459 (2002)
Intrinsic fluorescence of protoporphyrin IX from blood samples can yield information on the growth of prostate tumours
de Oliveira Silva FR, et al.
Journal of Fluorescence, 20(6), 1159-1165 (2010)
J Flemmig et al.
Free radical research, 50(12), 1386-1395 (2016-10-26)
Excessive release of hemoglobin from red blood cells markedly disturbs the health status of patients due to cytotoxic effects of free hemoglobin and heme. The latter component is able to initiate novel hemolytic events in unperturbed red blood cells. We
Feng Liu et al.
Sensors (Basel, Switzerland), 18(6) (2018-06-03)
A label-free sensing platform is developed based on switching the structure of aptamer for highly sensitive and selective fluorescence detection of ochratoxin A (OTA). OTA induces the structure of aptamer, transforms into G-quadruplex and produces strong fluorescence in the presence
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Dear Sir / Madam, Is any of your Protoporphyrin IX / Hemine products (sodium salt, ester, free acid) be classified as non-animal origin / sufficiently processed proven by analytical testing to show that the products are free of biological contaminants?
1 answer-
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