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M9808
Anti-Muscarinic Acetylcholine Receptor (M1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonim(y):
Acetylcholine Receptor antibody
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0.2 ML
4010,00 zł
4010,00 zł
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0.2 ML
4010,00 zł
About This Item
4010,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
lyophilized powder
reaktywność gatunkowa
mouse, rat
metody
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CHRM1(1128)
rat ... Chrm1(25229)
Opis ogólny
Muscarinic acetylcholine receptor 1 (M1) is a member of class A G protein-coupled receptors (GPCRs) family, which is encoded by the CHRM1 gene. Muscarinic receptors have seven transmembrane domains localized in the parasympathetic nerve sub-synaptic membrane. The CHRM1 gene is located on human chromosome location 11q12.3.
Muscarinic cholinergic receptor 1 (M1) is seen in the forebrain of rats.
Immunogen
GST fusion protein of a part of the i3 intracellular loop of human M1 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-353.1, 2
Zastosowanie
Anti-Muscarinic acetylcholine receptor (M1) antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Działania biochem./fizjol.
Muscarinic acetylcholine receptor 1 (M1) regulates normal prostate growth and reduced-level glandular secretion. Muscarinic receptors play a major role in tumor progression. Muscarinic acetylcholine receptors (mAChRs) regulates adenylyl cyclase and potassium channel activities. It also stimulates various mitogen-activated protein kinases. M1 may be useful for the discovery of therapeutics for Alzheimer′s disease.
Studies have shown that activation of muscarinic cholinergic receptor 1 (M1) in rats leads to changes in the endotoxin tolerance in the liver.
Postać fizyczna
Lyophilized from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Anna Rebeka Oliveira Ferreira et al.
Frontiers in physiology, 13, 840179-840179 (2022-05-17)
Perturbations to nutrition during critical periods are associated with changes in embryonic, fetal or postnatal developmental patterns that may render the offspring more likely to develop cardiovascular disease in later life. The aim of this study was to evaluate whether
Aurelia Lugea et al.
Alcoholism, clinical and experimental research, 34(10), 1768-1781 (2010-07-16)
The mechanisms initiating pancreatitis in patients with chronic alcohol abuse are poorly understood. Although alcohol feeding has been previously suggested to alter cholinergic pathways, the effects of these cholinergic alterations in promoting pancreatitis have not been characterized. For this study
Veronica C Galvin et al.
Neuron, 106(4), 649-661 (2020-03-21)
Working memory relies on the dorsolateral prefrontal cortex (dlPFC), where microcircuits of pyramidal neurons enable persistent firing in the absence of sensory input, maintaining information through recurrent excitation. This activity relies on acetylcholine, although the molecular mechanisms for this dependence
Sophie R Thomson et al.
Neuron, 95(3), 550-563 (2017-08-05)
Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
G Gireesh et al.
Journal of biomedical science, 16, 38-38 (2009-04-07)
Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the pathophysiology of many major diseases of the central
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