M9073

Anti-Mitofusin 2 antibody,Mouse monoclonal

clone Mito-2, purified from hybridoma cell culture

• Synonim(y): Anti-CMT2A, Anti-CMT2A2, Anti-CPRP1, Anti-HSG, Anti-Hyperplasia suppressor, Anti-KIAA0214, Anti-MARF, Anti-MFN2, Anti-Mitochondrial assembly regulatory factor, Anti-Transmembrane GTPase MFN2
• Numer MDL: MFCD03455396
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• białko sprzężone: unconjugated
• forma przeciwciała: purified from hybridoma cell culture
• rodzaj przeciwciała: primary antibodies
• klon: Mito-2, monoclonal
• Formularz: buffered aqueous solution
• masa cząsteczkowa: antigen ~86 kDa
• reaktywność gatunkowa: mouse, rat
• stężenie: ~1.0 mg/mL
• metody: western blot: 2-5 μg/mL using whole extract of rat brain mitochondria
• izotyp: IgG1
• numer dostępu UniProt: Q8R500
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... MFN2(9927)

Opis

Opis ogólny

Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein.

Monoclonal Anti-Mitofusin 2 (mouse IgG1 isotype) is derived from the hybridoma Mito-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human Mitofusin 2 conjugated to KLH. Mitofusin 2ismammalian homolog of the Drosophila protein fuzzy onion (Fzo). It is a transmembrane GTPases embedded in the outer membrane of mitochondria. Mitofusin 2 is broadly expressed, with highest expression in heart and skeletal muscle and is induced during myogenesis.

Zastosowanie

Anti-Mitofusin 2 antibody,Mouse monoclonal has been used in western blotting.

Działania biochem./fizjol.

Mitofusin 2 (Mfn2) mutant embryos have a specific and severe disruption of a layer of the placenta. Repression of Mfn2 causes morphological and functional fragmentation of the mitochondrial network into independent clusters and reduces mitochondrial membrane potential and glucose oxidation. Thus, this Mfn2-dependent regulatory mechanism is disturbed in obesity by reduced Mfn2 expression. Mutations in Mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, a neurological disorder that results from degeneration of axons in peripheral nerves.

Mitofusin-2 (MFN2) plays an important role as a mitochondrial fusion protein and controls many cell processes. It is mainly involved in regulating metabolic processes in the mitochondria. MFN2 prevents the formation of reactive oxygen species and controls endoplasmic reticulum stress. Mutations in the gene encoding this protein have been linked to diabetes and obesity.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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