M0896

MPTP Hydrochloride

≥98% (AgNO3), powder, dopaminergic neurotoxin

• Synonim(y): MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₅N · HCl
• Numer CAS: 23007-85-4
• Masa cząsteczkowa: 209.72
• Beilstein: 3707312
• Numer MDL: MFCD00012790
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24896578
• NACRES: NA.77

Właściwości

• Nazwa produktu: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
• Formularz: powder
• Poziom jakości: 200
• drug control: kontrollierte Droge in Deutschland
• kolor: white to off-white
• ciąg SMILES: Cl[H].CN1CCC(=CC1)c2ccccc2
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• Klucz InChI: KOWJANGMTAZWDT-UHFFFAOYSA-N

Opis

Opis ogólny

MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.

Zastosowanie

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:

• to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
• to study the behavioral impairments correlated to neurochemical deficits
• to study the effects of treadmill exercise on neuroprotection and neuroinflammation

MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.

Działania biochem./fizjol.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

Ostrzeżenie

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Inne uwagi

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H370
• Zwroty wskazujące środki ostrożności: P260 - P264 - P270 - P301 + P310 - P405 - P501
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - STOT SE 1
• Organy docelowe: Nervous system
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3